Daflon 500 mg. Bioflavonoids, particulary diosmin, oligomeric proanthocyanidin complexes (OPCs), and hesperidin, have showed efficacy in the treatment of hemorrhoids and varicose veins. These bioflavonoids show phlebotonic action, vasculoprotective effects, and antagonism of the biochemical mediators of inflammation. OPCs, diosmin, and hesperidin happen to be the topic of many clinical studies on efficacy and safety in the treatment of varicose veins and hemorrhoids.
There has been extensive research on the flavonoid mixture containing 90-percent diosmin and 10-percent hesperidin (Daflon 500, Les Laboratories, Servier, France). Several randomized controlled studies have established its efficacy in the treatment of varicose veins and hemorrhoids. The safety of these flavonoids has been established through animal scientific studies, and validated clinically in long-term trials. Facts gathered on over 2,850 patients given 450 mg diosmin and 50 mg hesperidin two tmes a day for up to 12 months confirms it is well tolerated and contains no contraindications to its use. Negative effects are unusual and mild with an incidence and nature just like that discovered with placebo in double-blind, managed trials.
A double-blind, placebo-controlled trial of 120 individuals documented the efficacy of Daflon in the treatment of acute and persistent the signs of hemorrhoids. The group was divided in half and matched at entry for basic characteristics, clinical characteristics, length of history, and acute episodes. Sufferers received the flavonoid mixture at a dose of two 500 mg tablets daily or placebo for two months. Subjects were evaluated on pain, pruritis, discharge, bleeding, edema, erythema, and bleeding on examination. Mean parameter results and overall symptom scores fell significantly in the treated group. Much the same double-blind, placebo-controlled analysis inspected 100 patients suffering an acute hemorrhoid attack. These patients received Daflon in a loading dose of three 500 mg tablets two times a day for the first 4 days and 2 tablets two times a day the next three days. The scientific severity of proctorrhagia, anal discomfort, discomfort, and anal discharge diminished to a higher extent in the treatment group.
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